Assay Detail

CHEMBL5232245

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Binding

Inhibition of AChE (unknown origin)

ChEMBL ↗

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Target

Acetylcholinesterase (CHEMBL220) ↗

Open DB target context

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Acetylcholinesterase (CHEMBL220) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Acetylcholinesterase

CHEMBL220

Anchored from Assay target.

Protein identity Acetylcholinesterase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Acetylcholinesterase (CHEMBL220) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Natural spirocyclic alkaloids and polyphenols as multi target dementia leads.

Hügel HM, de Silva NH, Siddiqui A, Blanch E, Lingham A.
Bioorg Med Chem (2021) 43 : 116270 -116270
PubMed 34153839 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.46	6.46

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL659	GALANTAMINE	4.0	1	6.46

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL659	GALANTAMINE	IC50	=	350.0	nM	6.46