Assay Detail
Binding
CHEMBL5232269
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Inhibition of MMP-9 (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of gelatinases (MMP-2 and MMP-9) for the management of hematological malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.79 | 9.17 |
| Ki | 1 | 10.52 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 10.52 |
| CHEMBL279786 | BATIMASTAT | 2.0 | 1 | 9.17 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 9.10 |
| CHEMBL76222 | REBIMASTAT | 2.0 | 1 | 7.57 |
| CHEMBL5277375 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL279786 | BATIMASTAT | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL76222 | REBIMASTAT | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5277375 | — | IC50 | = | 4830.0 | nM | 5.32 |