Assay Detail
Binding
CHEMBL5232313
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Binding affinity to human recombinant caspase 3 at 0.3125 to 5 uM measured after 400 secs by Surface plasmon resonance method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of Celastrol Derivatives with Improved Cytotoxic Selectivity and Antitumor Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 5.74 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4782984 | — | — | 1 | 6.05 |
| CHEMBL5268260 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4782984 | — | Kd | = | 900.0 | nM | 6.05 |
| CHEMBL5268260 | — | Kd | = | 3800.0 | nM | 5.42 |