Assay Detail
Binding
CHEMBL5233377
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Inhibition of mouse brain AChE
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An overview on the synthesis of carbohydrate-based molecules with biological activity related to neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.91 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3752685 | — | — | 1 | 8.72 |
| CHEMBL5288285 | — | — | 1 | 8.66 |
| CHEMBL4282214 | — | — | 1 | 8.32 |
| CHEMBL4294287 | — | — | 1 | 8.29 |
| CHEMBL5272055 | — | — | 1 | 8.12 |
| CHEMBL5282048 | — | — | 1 | 8.06 |
| CHEMBL4280262 | — | — | 1 | 8.00 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.47 |
| CHEMBL5285687 | — | — | 1 | 7.19 |
| CHEMBL4283717 | — | — | 1 | 7.08 |
| CHEMBL4276832 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3752685 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5288285 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4282214 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4294287 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5272055 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5282048 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL4280262 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL95 | TACRINE | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5285687 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4283717 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4276832 | — | IC50 | = | 90.0 | nM | 7.05 |