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Assay Detail

CHEMBL5233507

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Binding
Inhibition of human PD-1/PD-L1 interaction
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Publication

Progress in PD-1/PD-L1 pathway inhibitors: From biomacromolecules to small molecules.
Lin X, Lu X, Luo G, Xiang H.
Eur J Med Chem (2020) 186 : 111876 -111876
PubMed 31761384 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.80 8.85
EC50 1 9.14 9.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4445464 1 9.14
CHEMBL4071326 1 8.85
CHEMBL4084368 1 8.65
CHEMBL4081869 1 8.22
CHEMBL5274156 1 8.15
CHEMBL4089730 1 7.75
CHEMBL4062686 1 7.10
CHEMBL5275919 1 6.84
CHEMBL5282504 1 6.82
CHEMBL5274972 1 -
CHEMBL4637826 1 -
CHEMBL5287606 1 -
CHEMBL5272773 1 -
CHEMBL5290389 1 -
CHEMBL5275793 1 -
CHEMBL5278848 1 -
CHEMBL5273262 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4445464 EC50 = 0.72 nM 9.14
CHEMBL4071326 IC50 = 1.4 nM 8.85
CHEMBL4084368 IC50 = 2.25 nM 8.65
CHEMBL4081869 IC50 = 6.0 nM 8.22
CHEMBL5274156 IC50 = 7.0 nM 8.15
CHEMBL4089730 IC50 = 18.0 nM 7.75
CHEMBL4062686 IC50 = 80.0 nM 7.10
CHEMBL5275919 IC50 = 146.0 nM 6.84
CHEMBL5282504 IC50 = 153.0 nM 6.82
CHEMBL5274972 IC50 < 10.0 nM -
CHEMBL4637826 IC50 < 10.0 nM -
CHEMBL5287606 IC50 < 10.0 nM -
CHEMBL5272773 IC50 < 10.0 nM -
CHEMBL5290389 IC50 < 10.0 nM -
CHEMBL5275793 IC50 < 10.0 nM -
CHEMBL5278848 IC50 < 10.0 nM -
CHEMBL5273262 IC50 < 10.0 nM -