Assay Detail
Binding
CHEMBL5233540
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant STAT3 (unknown origin) expressed in baculovirus in Sf9 insect cells assessed as reduction in DNA binding activity with NIH3T3 nuclear extract incubated for 30 mins by electrophoretic mobility shift assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Revisiting signal transducer and activator of transcription 3 (STAT3) as an anticancer target and its inhibitor discovery: Where are we and where should we go?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.59 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1829876 | — | — | 1 | 5.17 |
| CHEMBL2172015 | — | — | 1 | 4.48 |
| CHEMBL1829786 | — | — | 1 | 4.46 |
| CHEMBL2172018 | — | — | 1 | 4.24 |
| CHEMBL5276064 | — | — | 1 | - |
| CHEMBL5280162 | — | — | 1 | - |
| CHEMBL3696067 | — | — | 1 | - |
| CHEMBL2431982 | — | — | 1 | - |
| CHEMBL5267613 | — | — | 1 | - |
| CHEMBL5279594 | — | — | 1 | - |
| CHEMBL5266557 | — | — | 1 | - |
| CHEMBL2431981 | — | — | 1 | - |
| CHEMBL5277946 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1829876 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2172015 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1829786 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL2172018 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL5276064 | — | IC50 | = | 182000.0 | nM | - |
| CHEMBL5280162 | — | IC50 | = | 217000.0 | nM | - |
| CHEMBL3696067 | — | IC50 | = | 255000.0 | nM | - |
| CHEMBL2431982 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5267613 | — | IC50 | = | 292000.0 | nM | - |
| CHEMBL5279594 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL5266557 | — | IC50 | = | 194000.0 | nM | - |
| CHEMBL2431981 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5277946 | — | IC50 | = | 235000.0 | nM | - |