Assay Detail
Binding
CHEMBL5234067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of USP7 (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ubiquitin carboxyl-terminal hydrolase 7 (CHEMBL2157850) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.77 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2159507 | — | — | 1 | 6.42 |
| CHEMBL2159503 | — | — | 1 | 6.42 |
| CHEMBL2159505 | — | — | 1 | 6.40 |
| CHEMBL2159504 | — | — | 1 | 6.37 |
| CHEMBL2159501 | — | — | 1 | 5.77 |
| CHEMBL2159500 | — | — | 1 | 5.70 |
| CHEMBL2159499 | — | — | 1 | 5.66 |
| CHEMBL2159497 | — | — | 1 | 5.16 |
| CHEMBL2159502 | — | — | 1 | 5.11 |
| CHEMBL2159506 | — | — | 1 | 4.72 |
| CHEMBL2159496 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2159507 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2159503 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2159505 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2159504 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2159501 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2159500 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2159499 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2159497 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL2159502 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2159506 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2159496 | — | IC50 | > | 31600.0 | nM | - |