Compound Detail
CHEMBL2159500
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Basic Information
| ChEMBL ID | CHEMBL2159500 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JZFGTMFJLSUORF-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
349.2
MW (Da)
4.71
ALogP
6
HBA
0
HBD
73.1
PSA (Ų)
0.45
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 47 CHEMBL2157851 | IC50 | 5.92 | 5.92 | 1200.0 | 2 |
| Ubiquitin carboxyl-terminal hydrolase 7 CHEMBL2157850 | IC50 | 5.7 | 5.7 | 2000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 47 | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of USP47 by Ub-CHOP reporter assay | 24900381 |
| Ubiquitin carboxyl-terminal hydrolase 47 | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of USP47 (unknown origin) | 32092586 |
| Ubiquitin carboxyl-terminal hydrolase 7 | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of USP7 (unknown origin) | 32092586 |
| Ubiquitin carboxyl-terminal hydrolase 7 | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of full length human USP7 (1 to 1102 residues) expressed in Escherich... | 38262120 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900381 | 10.1021/ml200276j | Ubiquitin carboxyl-terminal hydrolase 47 | 1 |
| 24900381 | 10.1021/ml200276j | No relevant target | 1 |
| 24900381 | 10.1021/ml200276j | Plasma | 1 |
| 24900381 | 10.1021/ml200276j | Caspase-3 | 1 |
| 24900381 | 10.1021/ml200276j | Ubiquitin carboxyl-terminal hydrolase 7 | 1 |
| 32092586 | 10.1016/j.ejmech.2020.112107 | Ubiquitin carboxyl-terminal hydrolase 47 | 1 |
| 32092586 | 10.1016/j.ejmech.2020.112107 | Ubiquitin carboxyl-terminal hydrolase 7 | 1 |
| 38262120 | 10.1016/j.ejmech.2024.116161 | Ubiquitin carboxyl-terminal hydrolase 7 | 1 |
Data from ChEMBL 36 via Core Engine