Assay Detail
Binding
CHEMBL5520159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length human USP7 (1 to 1102 residues) expressed in Escherichia coli BL21 (DE3) using Ubiquitin-AMC as substrate pre-incubated for 30 mins followed by substrate addition measured for 60 mins by fluorescence based analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ubiquitin carboxyl-terminal hydrolase 7 (CHEMBL2157850) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in the development of deubiquitinases inhibitors as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.05 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2159505 | — | — | 1 | 6.40 |
| CHEMBL2159500 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2159505 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2159500 | — | IC50 | = | 2000.0 | nM | 5.70 |