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Assay Detail

CHEMBL5234065

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of USP47 (unknown origin)
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Ubiquitin carboxyl-terminal hydrolase 47 (CHEMBL2157851)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors.
Li P, Liu HM.
Eur J Med Chem (2020) 191 : 112107 -112107
PubMed 32092586 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.70 6.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2159507 1 6.46
CHEMBL2398212 1 6.40
CHEMBL2159505 1 6.30
CHEMBL2159503 1 6.28
CHEMBL2159504 1 6.06
CHEMBL2159500 1 5.92
CHEMBL2159501 1 5.89
CHEMBL2159499 1 5.66
CHEMBL4569978 1 5.46
CHEMBL5281075 1 5.37
CHEMBL2159502 1 5.26
CHEMBL2159496 1 4.85
CHEMBL5283229 1 4.18
CHEMBL4516637 1 -
CHEMBL5274053 1 -
CHEMBL5276519 1 -
CHEMBL5270413 1 -
CHEMBL4438288 1 -
CHEMBL5286198 1 -
CHEMBL5277194 1 -
CHEMBL2159506 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2159507 IC50 = 350.0 nM 6.46
CHEMBL2398212 IC50 = 400.0 nM 6.40
CHEMBL2159505 IC50 = 500.0 nM 6.30
CHEMBL2159503 IC50 = 530.0 nM 6.28
CHEMBL2159504 IC50 = 870.0 nM 6.06
CHEMBL2159500 IC50 = 1200.0 nM 5.92
CHEMBL2159501 IC50 = 1300.0 nM 5.89
CHEMBL2159499 IC50 = 2200.0 nM 5.66
CHEMBL4569978 IC50 = 3500.0 nM 5.46
CHEMBL5281075 IC50 = 4300.0 nM 5.37
CHEMBL2159502 IC50 = 5500.0 nM 5.26
CHEMBL2159496 IC50 = 14000.0 nM 4.85
CHEMBL5283229 IC50 = 66000.0 nM 4.18
CHEMBL4516637 IC50 > 100000.0 nM -
CHEMBL5274053 IC50 > 100000.0 nM -
CHEMBL5276519 IC50 > 100000.0 nM -
CHEMBL5270413 IC50 > 100000.0 nM -
CHEMBL4438288 IC50 > 100000.0 nM -
CHEMBL5286198 IC50 > 100000.0 nM -
CHEMBL5277194 IC50 > 100000.0 nM -
CHEMBL2159506 IC50 > 31600.0 nM -