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Assay Detail

CHEMBL2162865

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of USP47 by Ub-CHOP reporter assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Ubiquitin carboxyl-terminal hydrolase 47 (CHEMBL2157851)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47.
Weinstock J, Wu J, Cao P, Kingsbury WD, McDermott JL, Kodrasov MP, McKelvey DM, Suresh Kumar KG, Goldenberg SJ, Mattern MR, Nicholson B.
ACS Med Chem Lett (2012) 3 : 789 -792
PubMed 24900381 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.73 6.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2159507 1 6.46
CHEMBL2159505 1 6.30
CHEMBL2159503 1 6.28
CHEMBL2159504 1 6.06
CHEMBL2159508 1 6.00
CHEMBL2159500 1 5.92
CHEMBL2159501 1 5.89
CHEMBL2159499 1 5.66
CHEMBL2159497 1 5.43
CHEMBL2159495 1 5.37
CHEMBL2159502 1 5.26
CHEMBL2159498 1 5.06
CHEMBL2159496 1 4.85
CHEMBL2159506 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2159507 IC50 = 350.0 nM 6.46
CHEMBL2159505 IC50 = 500.0 nM 6.30
CHEMBL2159503 IC50 = 530.0 nM 6.28
CHEMBL2159504 IC50 = 870.0 nM 6.06
CHEMBL2159508 IC50 = 1000.0 nM 6.00
CHEMBL2159500 IC50 = 1200.0 nM 5.92
CHEMBL2159501 IC50 = 1300.0 nM 5.89
CHEMBL2159499 IC50 = 2200.0 nM 5.66
CHEMBL2159497 IC50 = 3700.0 nM 5.43
CHEMBL2159495 IC50 = 4300.0 nM 5.37
CHEMBL2159502 IC50 = 5500.0 nM 5.26
CHEMBL2159498 IC50 = 8700.0 nM 5.06
CHEMBL2159496 IC50 = 14000.0 nM 4.85
CHEMBL2159506 IC50 > 31600.0 nM -