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Assay Detail

CHEMBL5234151

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant full length human HDAC3 expressed in insect Sf9 cells at 10 uM measured after 1 hr by EMSA analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Sf9
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase 3 (CHEMBL1829)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Histone deacetylase 3 (HDAC3) inhibitors as anticancer agents: A review.
Sarkar R, Banerjee S, Amin SA, Adhikari N, Jha T.
Eur J Med Chem (2020) 192 : 112171 -112171
PubMed 32163814 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.22 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3970532 1 7.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3970532 IC50 = 60.0 nM 7.22