Assay Detail
Binding
CHEMBL5234249
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Agonist activity in TLR8 (unknown origin) expressed in HEK293 cells assessed as induction of NF-kappa activation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.48 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5275885 | — | — | 1 | 7.52 |
| CHEMBL512901 | — | — | 1 | 6.10 |
| CHEMBL383322 | RESIQUIMOD | 2.0 | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5275885 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL512901 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL383322 | RESIQUIMOD | EC50 | = | 1500.0 | nM | 5.82 |