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Assay Detail

CHEMBL5234262

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MMP-1 (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Interstitial collagenase (CHEMBL332)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview.
Mondal S, Adhikari N, Banerjee S, Amin SA, Jha T.
Eur J Med Chem (2020) 194 : 112260 -112260
PubMed 32224379 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.52 7.65

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL437017 1 7.65
CHEMBL427616 1 7.54
CHEMBL267178 1 7.48
CHEMBL5278767 1 7.13
CHEMBL5272175 1 6.67
CHEMBL5269115 1 6.27
CHEMBL5278204 1 6.22
CHEMBL310655 1 6.21
CHEMBL34206 1 5.70
CHEMBL5281827 1 5.51
CHEMBL319808 1 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL437017 IC50 = 22.2 nM 7.65
CHEMBL427616 IC50 = 28.9 nM 7.54
CHEMBL267178 IC50 = 33.0 nM 7.48
CHEMBL5278767 IC50 = 74.0 nM 7.13
CHEMBL5272175 IC50 = 213.0 nM 6.67
CHEMBL5269115 IC50 = 542.0 nM 6.27
CHEMBL5278204 IC50 = 608.0 nM 6.22
CHEMBL310655 IC50 = 618.0 nM 6.21
CHEMBL34206 IC50 = 2000.0 nM 5.70
CHEMBL5281827 IC50 = 3100.0 nM 5.51
CHEMBL319808 IC50 = 4982.0 nM 5.30