Assay Detail
Binding
CHEMBL5234366
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Inhibition of wild type Staphylococcus aureus DHFR
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dihydrofolate reductase inhibitors for use as antimicrobial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.12 | 8.54 |
| Ki | 1 | 8.40 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1235617 | — | — | 1 | 8.54 |
| CHEMBL5287382 | — | — | 1 | 8.40 |
| CHEMBL4483572 | — | — | 1 | 7.82 |
| CHEMBL5284400 | — | — | 1 | 7.75 |
| CHEMBL5283880 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1235617 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5287382 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4483572 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5284400 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5283880 | — | IC50 | = | 41500.0 | nM | 4.38 |