Assay Detail
Binding
CHEMBL5234416
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Inhibition of MCT4 (unknown origin) assessed as reduction in [14C]lactate uptake incubated for 20 mins by liquid scintillation counting analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.48 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3582419 | — | — | 1 | 7.85 |
| CHEMBL3582420 | — | — | 1 | 7.77 |
| CHEMBL3582422 | — | — | 1 | 7.64 |
| CHEMBL3892299 | — | — | 1 | 7.50 |
| CHEMBL3582500 | — | — | 1 | 7.28 |
| CHEMBL3582501 | — | — | 1 | 7.24 |
| CHEMBL3582421 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3582419 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3582420 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3582422 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3892299 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3582500 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3582501 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3582421 | — | IC50 | = | 85.0 | nM | 7.07 |