Assay Detail
Functional
CHEMBL5235231
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NF-kappaB activation incubated for 24 hrs by SEAP microplate reader analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-inflammatory activity of naturally occuring diarylheptanoids - A review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.24 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL465158 | — | — | 1 | 5.47 |
| CHEMBL455297 | HIRSUTANONOL | — | 1 | 5.00 |
| CHEMBL464274 | DEHYDROHIRSUTANONOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL465158 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL455297 | HIRSUTANONOL | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL464274 | DEHYDROHIRSUTANONOL | IC50 | > | 100000.0 | nM | - |