Assay Detail
Binding
CHEMBL5235442
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Displacement of [3H]-methylspiperone from D4 (unknown origin) receptor expressed in HEK293T cells assessed as inhibition constant
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent findings leading to the discovery of selective dopamine D<sub>4</sub> receptor ligands for the treatment of widespread diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.02 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3480577 | UCSF924 | — | 1 | 8.52 |
| CHEMBL5290993 | — | — | 1 | 8.37 |
| CHEMBL5278957 | — | — | 1 | 7.10 |
| CHEMBL5290570 | — | — | 1 | 6.89 |
| CHEMBL5272829 | — | — | 1 | 6.85 |
| CHEMBL5277325 | — | — | 1 | 6.82 |
| CHEMBL5283608 | — | — | 1 | 6.50 |
| CHEMBL5267339 | — | — | 1 | 6.30 |
| CHEMBL5289845 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3480577 | UCSF924 | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL5290993 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL5278957 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL5290570 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL5272829 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL5277325 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL5283608 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL5267339 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL5289845 | — | Ki | = | 1380.0 | nM | 5.86 |