Compound Detail
CHEMBL5283608
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5283608 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CDDSADAPSRSSJF-MRXNPFEDSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
345.5
MW (Da)
2.99
ALogP
6
HBA
0
HBD
47.4
PSA (Ų)
0.75
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.97
Ki 1 meas. best 6.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(4) dopamine receptor CHEMBL219 | Ki | 6.5 | 6.5 | 320.0 | 1 |
| D(4) dopamine receptor CHEMBL219 | EC50 | 4.97 | 4.97 | 10800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(4) dopamine receptor | Ki | = | 320.0 | nM | 6.5 | Displacement of [3H]-methylspiperone from D4 (unknown origin) receptor expressed... | 33422983 |
| D(4) dopamine receptor | EC50 | = | 10800.0 | nM | 4.97 | Agonist activity at D4R (unknown origin) by camp reporter assay | 33422983 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33422983 | 10.1016/j.ejmech.2020.113141 | D(4) dopamine receptor | 2 |
| 33422983 | 10.1016/j.ejmech.2020.113141 | D(2) dopamine receptor | 1 |
| 33422983 | 10.1016/j.ejmech.2020.113141 | D(3) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine