Assay Detail
Binding
CHEMBL5235458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRD4 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting MYC: From understanding its biology to drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.16 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3987016 | MIVEBRESIB | 2.0 | 1 | 8.52 |
| CHEMBL4078100 | AZD-5153 | 1.0 | 1 | 8.30 |
| CHEMBL1232461 | MOLIBRESIB | 2.0 | 1 | 7.52 |
| CHEMBL4303404 | PELABRESIB | 3.0 | 1 | 7.41 |
| CHEMBL9 | NORFLOXACIN | 4.0 | 1 | 6.01 |
| CHEMBL225164 | CLOXYQUIN | 2.0 | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3987016 | MIVEBRESIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4078100 | AZD-5153 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1232461 | MOLIBRESIB | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4303404 | PELABRESIB | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL9 | NORFLOXACIN | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL225164 | CLOXYQUIN | IC50 | = | 6470.0 | nM | 5.19 |