Assay Detail
Binding
CHEMBL5235544
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DYRK1A (unknown origin)
18
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (CHEMBL2292) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
β-Carboline as a Privileged Scaffold for Multitarget Strategies in Alzheimer's Disease Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.75 | 7.66 |
| IC5 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269538 | HARMINE | 1.0 | 1 | 7.66 |
| CHEMBL4474836 | — | — | 1 | 7.60 |
| CHEMBL44889 | — | — | 2 | 7.46 |
| CHEMBL4460242 | — | — | 1 | 7.46 |
| CHEMBL325351 | — | — | 1 | 7.46 |
| CHEMBL4514653 | — | — | 1 | 7.46 |
| CHEMBL4159941 | — | — | 1 | 7.25 |
| CHEMBL5289480 | — | — | 1 | 7.25 |
| CHEMBL4066450 | — | — | 1 | 7.25 |
| CHEMBL5267999 | — | — | 1 | 5.70 |
| CHEMBL5286216 | — | — | 1 | 5.70 |
| CHEMBL5279996 | — | — | 1 | 5.70 |
| CHEMBL340807 | HARMALINE | — | 1 | 5.34 |
| CHEMBL5276049 | — | — | 1 | 4.57 |
| CHEMBL5280284 | — | — | 1 | - |
| CHEMBL12014 | HARMAN | — | 1 | - |
| CHEMBL275224 | NORHARMANE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269538 | HARMINE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4474836 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL44889 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4460242 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL325351 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4514653 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL44889 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4159941 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5289480 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4066450 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5286216 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5279996 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5267999 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL340807 | HARMALINE | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5276049 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL5280284 | — | IC5 | = | 0.2 | uM | - |
| CHEMBL12014 | HARMAN | IC50 | > | 1800.0 | nM | - |
| CHEMBL275224 | NORHARMANE | IC50 | > | 1800.0 | nM | - |