Assay Detail
Binding
CHEMBL5236041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse MOR expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding incubated for 60 mins by scintillation spectroscopy analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Oxidative Metabolism as a Modulator of Kratom's Biological Actions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.80 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5276728 | — | — | 1 | 7.17 |
| CHEMBL292521 | — | — | 1 | 6.37 |
| CHEMBL5287921 | — | — | 1 | 5.24 |
| CHEMBL4859858 | — | — | 1 | 5.21 |
| CHEMBL4848517 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5276728 | — | EC50 | = | 67.5 | nM | 7.17 |
| CHEMBL292521 | — | EC50 | = | 422.4 | nM | 6.37 |
| CHEMBL5287921 | — | EC50 | = | 5778.0 | nM | 5.24 |
| CHEMBL4859858 | — | EC50 | = | 6225.7 | nM | 5.21 |
| CHEMBL4848517 | — | EC50 | = | 9384.0 | nM | 5.03 |