Assay Detail
Binding
CHEMBL5236192
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Agonist activity at FXR in human HeLa cells by Dual-Glo luciferase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Advances in the Medicinal Chemistry of Farnesoid X Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.64 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5269567 | — | — | 1 | 10.05 |
| CHEMBL5271104 | — | — | 1 | 9.52 |
| CHEMBL4870713 | — | — | 1 | 8.04 |
| CHEMBL4860451 | — | — | 1 | 8.00 |
| CHEMBL5290019 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5269567 | — | EC50 | = | 0.09 | nM | 10.05 |
| CHEMBL5271104 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4870713 | — | EC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4860451 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5290019 | — | EC50 | = | 26.0 | nM | 7.58 |