Assay Detail
Binding
CHEMBL5236198
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at FXR in human HeLa cells incubated for 24 hrs by Dual-Glo luciferase assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Advances in the Medicinal Chemistry of Farnesoid X Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.95 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5272705 | — | — | 1 | 6.64 |
| CHEMBL5281274 | — | — | 1 | 6.58 |
| CHEMBL5272000 | — | — | 1 | 6.52 |
| CHEMBL4632533 | — | — | 1 | 6.10 |
| CHEMBL5273108 | — | — | 1 | 5.46 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 1 | 5.41 |
| CHEMBL5283234 | — | — | 1 | 4.96 |
| CHEMBL4633499 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5272705 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5281274 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5272000 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4632533 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5273108 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL603 | ZAFIRLUKAST | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5283234 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4633499 | — | EC50 | = | 940000.0 | nM | - |