Assay Detail
Binding
CHEMBL5236424
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Inhibition of PCSK9-LDLR (unknown origin) protein-protein interaction
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Recent Update on the Development of PCSK9 Inhibitors for Hypercholesterolemia Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.86 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5278292 | — | — | 1 | 8.70 |
| CHEMBL5278854 | — | — | 1 | 6.16 |
| CHEMBL4226740 | — | — | 1 | 6.10 |
| CHEMBL5287357 | — | — | 1 | 5.80 |
| CHEMBL5277547 | — | — | 1 | 5.77 |
| CHEMBL4228379 | — | — | 1 | 4.95 |
| CHEMBL5285300 | — | — | 1 | 4.84 |
| CHEMBL5094892 | — | — | 1 | 4.57 |
| CHEMBL4472590 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5278292 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5278854 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4226740 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5287357 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5277547 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4228379 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL5285300 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL5094892 | — | IC50 | = | 27120.0 | nM | 4.57 |
| CHEMBL4472590 | — | IC50 | = | 285600.0 | nM | - |