Assay Detail
Binding
CHEMBL5236725
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE4B
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Furazans in Medicinal Chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.66 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193240 | ROFLUMILAST | 4.0 | 1 | 9.15 |
| CHEMBL77826 | — | — | 1 | 7.47 |
| CHEMBL2172374 | — | — | 1 | 7.47 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193240 | ROFLUMILAST | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL77826 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2172374 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 288.0 | nM | 6.54 |