Assay Detail
Functional
CHEMBL5237334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 harboring integrase E138K/Q148K mutant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Advances in the development of HIV integrase strand transfer inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.70 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5287175 | — | — | 1 | 7.80 |
| CHEMBL1229211 | DOLUTEGRAVIR | 4.0 | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5287175 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1229211 | DOLUTEGRAVIR | EC50 | = | 25.0 | nM | 7.60 |