Assay Detail
Functional
CHEMBL5237336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 harboring integrase Q148R mutant
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Advances in the development of HIV integrase strand transfer inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.10 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1237000 | — | — | 1 | 9.00 |
| CHEMBL5269335 | — | — | 1 | 9.00 |
| CHEMBL5289058 | — | — | 1 | 8.82 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 7.80 |
| CHEMBL4641780 | — | — | 1 | 7.48 |
| CHEMBL4126289 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1237000 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5269335 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5289058 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL254316 | RALTEGRAVIR | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4641780 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4126289 | — | EC50 | = | 300.0 | nM | 6.52 |