Assay Detail
Binding
CHEMBL5237428
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Inhibition of KDM5B (unknown origin ) by Alphascreen assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacological inhibition of KDM5A for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.57 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5277258 | — | — | 1 | 8.15 |
| CHEMBL4078388 | — | — | 1 | 7.72 |
| CHEMBL5287501 | — | — | 1 | 7.62 |
| CHEMBL5273968 | — | — | 1 | 7.60 |
| CHEMBL5285505 | — | — | 1 | 7.19 |
| CHEMBL3786593 | — | — | 1 | 6.48 |
| CHEMBL5269420 | — | — | 1 | 5.18 |
| CHEMBL5279892 | — | — | 1 | 5.16 |
| CHEMBL5278119 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5277258 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4078388 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5287501 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5273968 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5285505 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3786593 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5269420 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL5279892 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5278119 | — | IC50 | = | 100000.0 | nM | 4.00 |