Assay Detail
Binding
CHEMBL5237482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kbeta (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Imidazo[1,2-b]pyridazine as privileged scaffold in medicinal chemistry: An extensive review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.37 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5268567 | — | — | 1 | 9.30 |
| CHEMBL5272007 | — | — | 1 | 9.00 |
| CHEMBL5282271 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5268567 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5272007 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5282271 | — | IC50 | = | 150.0 | nM | 6.82 |