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Assay Detail

CHEMBL5237491

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PAR2 expressed in human HT-29 cells incubated for 30 mins by FLIPR Tetra system method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HT-29
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Proteinase-activated receptor 2 (CHEMBL5963)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Imidazo[1,2-b]pyridazine as privileged scaffold in medicinal chemistry: An extensive review.
Garrido A, Vera G, Delaye PO, Enguehard-Gueiffier C.
Eur J Med Chem (2021) 226 : 113867 -113867
PubMed 34607244 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 9.15 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5273903 1 9.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5273903 IC50 = 0.7 nM 9.15