Assay Detail
Binding
CHEMBL5237550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-arginine methyltransferase CARM1 (CHEMBL5406) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 8.16 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5272699 | — | — | 1 | 9.19 |
| CHEMBL5270700 | — | — | 1 | 9.11 |
| CHEMBL5274219 | — | — | 1 | 9.04 |
| CHEMBL5291238 | — | — | 1 | 8.96 |
| CHEMBL5271782 | — | — | 1 | 8.95 |
| CHEMBL5288947 | — | — | 1 | 8.79 |
| CHEMBL5283756 | — | — | 1 | 8.64 |
| CHEMBL5287824 | — | — | 1 | 8.61 |
| CHEMBL5271800 | — | — | 1 | 8.53 |
| CHEMBL5266562 | — | — | 1 | 8.43 |
| CHEMBL5289496 | — | — | 1 | 8.43 |
| CHEMBL5284876 | — | — | 1 | 8.42 |
| CHEMBL5289683 | — | — | 1 | 8.42 |
| CHEMBL5268692 | — | — | 1 | 8.37 |
| CHEMBL5274541 | — | — | 1 | 8.37 |
| CHEMBL5277620 | — | — | 1 | 8.36 |
| CHEMBL5273938 | — | — | 1 | 8.29 |
| CHEMBL5279093 | — | — | 1 | 8.28 |
| CHEMBL5290292 | — | — | 1 | 8.22 |
| CHEMBL5269937 | — | — | 1 | 8.21 |
| CHEMBL5289773 | — | — | 1 | 7.99 |
| CHEMBL5290611 | — | — | 1 | 7.99 |
| CHEMBL5285757 | — | — | 1 | 7.94 |
| CHEMBL5266548 | — | — | 1 | 7.93 |
| CHEMBL5270405 | — | — | 1 | 7.93 |
| CHEMBL5279447 | — | — | 1 | 7.88 |
| CHEMBL5271681 | — | — | 1 | 7.71 |
| CHEMBL5287686 | — | — | 1 | 7.67 |
| CHEMBL5289833 | — | — | 1 | 7.66 |
| CHEMBL5266710 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5272699 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL5270700 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL5274219 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL5291238 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5271782 | — | IC50 | = | 1.13 | nM | 8.95 |
| CHEMBL5288947 | — | IC50 | = | 1.63 | nM | 8.79 |
| CHEMBL5283756 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5287824 | — | IC50 | = | 2.46 | nM | 8.61 |
| CHEMBL5271800 | — | IC50 | = | 2.94 | nM | 8.53 |
| CHEMBL5266562 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5289496 | — | IC50 | = | 3.68 | nM | 8.43 |
| CHEMBL5284876 | — | IC50 | = | 3.84 | nM | 8.42 |
| CHEMBL5289683 | — | IC50 | = | 3.78 | nM | 8.42 |
| CHEMBL5268692 | — | IC50 | = | 4.24 | nM | 8.37 |
| CHEMBL5274541 | — | IC50 | = | 4.29 | nM | 8.37 |
| CHEMBL5277620 | — | IC50 | = | 4.37 | nM | 8.36 |
| CHEMBL5273938 | — | IC50 | = | 5.13 | nM | 8.29 |
| CHEMBL5279093 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL5290292 | — | IC50 | = | 6.07 | nM | 8.22 |
| CHEMBL5269937 | — | IC50 | = | 6.15 | nM | 8.21 |
| CHEMBL5290611 | — | IC50 | = | 10.18 | nM | 7.99 |
| CHEMBL5289773 | — | IC50 | = | 10.13 | nM | 7.99 |
| CHEMBL5285757 | — | IC50 | = | 11.52 | nM | 7.94 |
| CHEMBL5266548 | — | IC50 | = | 11.84 | nM | 7.93 |
| CHEMBL5270405 | — | IC50 | = | 11.63 | nM | 7.93 |
| CHEMBL5279447 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL5271681 | — | IC50 | = | 19.62 | nM | 7.71 |
| CHEMBL5287686 | — | IC50 | = | 21.45 | nM | 7.67 |
| CHEMBL5289833 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL5266710 | — | IC50 | = | 26.86 | nM | 7.57 |
| CHEMBL5278488 | — | IC50 | = | 29.43 | nM | 7.53 |
| CHEMBL5279188 | — | IC50 | = | 29.54 | nM | 7.53 |
| CHEMBL5288079 | — | IC50 | = | 31.46 | nM | 7.50 |
| CHEMBL5277762 | — | IC50 | = | 33.61 | nM | 7.47 |
| CHEMBL5290686 | — | IC50 | = | 60.05 | nM | 7.22 |
| CHEMBL5267045 | — | IC50 | = | 187.06 | nM | 6.73 |
| CHEMBL5288432 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5286582 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5275579 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5266735 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5266897 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5280681 | — | IC50 | > | 1000.0 | nM | - |