Assay Detail
Binding
CHEMBL5238024
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EZH2 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase EZH2 (CHEMBL2189110) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Blocking Non-enzymatic Functions by PROTAC-Mediated Targeted Protein Degradation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.80 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5280243 | — | — | 1 | 8.15 |
| CHEMBL5289343 | — | — | 1 | 7.89 |
| CHEMBL4532174 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5280243 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5289343 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4532174 | — | IC50 | = | 44.0 | nM | 7.36 |