Compound Detail
CHEMBL5289343
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CCN(c1cc(-c2ccc(CN3CCN(C(=O)CCCCCCCC(=O)N[C@H](C(=O)N4C[C@H](OCc5ccccc5)C[C@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)CC3)cc2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1
Basic Information
| ChEMBL ID | CHEMBL5289343 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FSADQQRGHMBQEA-ABRLEHMRSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1244.7
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EZH2 CHEMBL2189110 | IC50 | 7.89 | 7.89 | 13.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EZH2 | IC50 | = | 13.0 | nM | 7.89 | Inhibition of EZH2 (unknown origin) | 36306471 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36306471 | 10.1021/acs.jmedchem.2c01159 | Histone-lysine N-methyltransferase EZH2 | 1 |
| 36306471 | 10.1021/acs.jmedchem.2c01159 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine