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Assay Detail

CHEMBL5238146

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Induction of progranulin secretion in mouse BV-2 cells
ChEMBL ↗
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type BV-2
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Discovery of oxazoline enhancers of cellular progranulin release.
Peng X, Lanter JC, Y-P Chen A, Brand MA, Wozniak MK, Hoekman S, Longin O, Regeling H, Zonneveld W, P L Bell R, Koenig G, Hurst RS, Blain JF, Burnett DA.
Bioorg Med Chem Lett (2023) 80 : 129048 -129048
PubMed 36368496 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 60 6.67 7.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5273957 — — 1 7.68
CHEMBL5268245 — — 1 7.46
CHEMBL5271685 — — 1 7.43
CHEMBL5276003 — — 1 7.42
CHEMBL5269880 — — 1 7.42
CHEMBL5288607 — — 1 7.26
CHEMBL5289562 — — 1 7.24
CHEMBL5279295 — — 1 7.23
CHEMBL5285823 — — 1 7.19
CHEMBL5270350 — — 1 7.16
CHEMBL5287100 — — 1 7.08
CHEMBL5273870 — — 1 7.07
CHEMBL5286140 — — 1 7.07
CHEMBL5281792 — — 1 7.01
CHEMBL5287163 — — 1 6.96
CHEMBL5288288 — — 1 6.96
CHEMBL5279044 — — 1 6.96
CHEMBL5284190 — — 1 6.92
CHEMBL5272819 — — 1 6.92
CHEMBL5280647 — — 1 6.90
CHEMBL5286054 — — 1 6.90
CHEMBL5285699 — — 1 6.88
CHEMBL5281603 — — 1 6.86
CHEMBL5288768 — — 1 6.80
CHEMBL5269478 — — 1 6.80
CHEMBL5267232 — — 1 6.75
CHEMBL5267767 — — 1 6.74
CHEMBL5268324 — — 1 6.72
CHEMBL5276265 — — 1 6.69
CHEMBL5269596 — — 1 6.69

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5273957 — EC50 = 21.0 nM 7.68
CHEMBL5268245 — EC50 = 35.0 nM 7.46
CHEMBL5271685 — EC50 = 37.0 nM 7.43
CHEMBL5276003 — EC50 = 38.0 nM 7.42
CHEMBL5269880 — EC50 = 38.0 nM 7.42
CHEMBL5288607 — EC50 = 55.0 nM 7.26
CHEMBL5289562 — EC50 = 57.0 nM 7.24
CHEMBL5279295 — EC50 = 59.0 nM 7.23
CHEMBL5285823 — EC50 = 64.0 nM 7.19
CHEMBL5270350 — EC50 = 69.0 nM 7.16
CHEMBL5287100 — EC50 = 83.0 nM 7.08
CHEMBL5273870 — EC50 = 85.0 nM 7.07
CHEMBL5286140 — EC50 = 85.0 nM 7.07
CHEMBL5281792 — EC50 = 97.0 nM 7.01
CHEMBL5279044 — EC50 = 111.0 nM 6.96
CHEMBL5288288 — EC50 = 109.0 nM 6.96
CHEMBL5287163 — EC50 = 110.0 nM 6.96
CHEMBL5284190 — EC50 = 119.0 nM 6.92
CHEMBL5272819 — EC50 = 119.0 nM 6.92
CHEMBL5280647 — EC50 = 127.0 nM 6.90
CHEMBL5286054 — EC50 = 126.0 nM 6.90
CHEMBL5285699 — EC50 = 132.0 nM 6.88
CHEMBL5281603 — EC50 = 137.0 nM 6.86
CHEMBL5288768 — EC50 = 157.0 nM 6.80
CHEMBL5269478 — EC50 = 160.0 nM 6.80
CHEMBL5267232 — EC50 = 176.0 nM 6.75
CHEMBL5267767 — EC50 = 181.0 nM 6.74
CHEMBL5268324 — EC50 = 192.0 nM 6.72
CHEMBL5276265 — EC50 = 204.0 nM 6.69
CHEMBL5269596 — EC50 = 206.0 nM 6.69
CHEMBL5275548 — EC50 = 208.0 nM 6.68
CHEMBL5289822 — EC50 = 209.0 nM 6.68
CHEMBL5290639 — EC50 = 218.0 nM 6.66
CHEMBL5289712 — EC50 = 231.0 nM 6.64
CHEMBL5274897 — EC50 = 230.0 nM 6.64
CHEMBL5270875 — EC50 = 236.0 nM 6.63
CHEMBL5280684 — EC50 = 237.0 nM 6.62
CHEMBL5287033 — EC50 = 244.0 nM 6.61
CHEMBL5284728 — EC50 = 257.0 nM 6.59
CHEMBL5288534 — EC50 = 275.0 nM 6.56
CHEMBL5271222 — EC50 = 318.0 nM 6.50
CHEMBL5282098 — EC50 = 335.0 nM 6.47
CHEMBL5282965 — EC50 = 382.0 nM 6.42
CHEMBL5278585 — EC50 = 387.0 nM 6.41
CHEMBL5269980 — EC50 = 423.0 nM 6.37
CHEMBL5265949 — EC50 = 455.0 nM 6.34
CHEMBL5278793 — EC50 = 502.0 nM 6.30
CHEMBL5284980 — EC50 = 517.0 nM 6.29
CHEMBL5280233 — EC50 = 522.0 nM 6.28
CHEMBL5270897 — EC50 = 639.0 nM 6.19