Assay Detail
Binding
CHEMBL5238847
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse EGFR D770_N771insNPG mutant stably expressed in mouse BaF3 cells assessed as cell viability incubated for 3 days by Cell Titer-Glo assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.83 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5266100 | — | — | 1 | 8.52 |
| CHEMBL4650319 | MOBOCERTINIB | 4.0 | 1 | 8.40 |
| CHEMBL5283216 | — | — | 1 | 8.40 |
| CHEMBL5266798 | — | — | 1 | 8.30 |
| CHEMBL5281266 | — | — | 1 | 8.30 |
| CHEMBL5290929 | — | — | 1 | 8.22 |
| CHEMBL5268143 | — | — | 1 | 8.22 |
| CHEMBL5270000 | — | — | 1 | 8.21 |
| CHEMBL5275712 | — | — | 1 | 8.19 |
| CHEMBL5279794 | — | — | 1 | 8.18 |
| CHEMBL5286091 | — | — | 1 | 8.18 |
| CHEMBL5270335 | — | — | 1 | 8.10 |
| CHEMBL5284486 | — | — | 1 | 8.10 |
| CHEMBL5271640 | — | — | 1 | 8.05 |
| CHEMBL5273438 | — | — | 1 | 8.05 |
| CHEMBL5279491 | — | — | 1 | 8.01 |
| CHEMBL5271718 | — | — | 1 | 7.96 |
| CHEMBL5266834 | — | — | 1 | 7.96 |
| CHEMBL5284387 | — | — | 1 | 7.89 |
| CHEMBL5272345 | — | — | 1 | 7.85 |
| CHEMBL5284255 | — | — | 1 | 7.82 |
| CHEMBL5266482 | — | — | 1 | 7.66 |
| CHEMBL5281203 | — | — | 1 | 7.64 |
| CHEMBL3353404 | — | — | 1 | 7.50 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.44 |
| CHEMBL5276760 | — | — | 1 | 7.42 |
| CHEMBL5291010 | — | — | 1 | 7.28 |
| CHEMBL5266896 | — | — | 1 | 7.28 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.28 |
| CHEMBL4104658 | — | — | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5266100 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4650319 | MOBOCERTINIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5283216 | — | IC50 | = | 3.99 | nM | 8.40 |
| CHEMBL5266798 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5281266 | — | IC50 | = | 4.95 | nM | 8.30 |
| CHEMBL5290929 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5268143 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5270000 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5275712 | — | IC50 | = | 6.43 | nM | 8.19 |
| CHEMBL5279794 | — | IC50 | = | 6.57 | nM | 8.18 |
| CHEMBL5286091 | — | IC50 | = | 6.57 | nM | 8.18 |
| CHEMBL5270335 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5284486 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5271640 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5273438 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5279491 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL5271718 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5266834 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5284387 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5272345 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5284255 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5266482 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5281203 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3353404 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5276760 | — | IC50 | = | 37.6 | nM | 7.42 |
| CHEMBL5291010 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5266896 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4104658 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3545308 | ROCILETINIB | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL5286532 | — | IC50 | = | 754.0 | nM | 6.12 |