Compound Detail
CHEMBL5290929
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C=CC(=O)Nc1cc(Nc2ncc(C(=O)OC(C)C)c(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)C[C@H]1CCCN1C
Basic Information
| ChEMBL ID | CHEMBL5290929 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MILBIPKHYWBIPY-JOCHJYFZSA-N |
2
Targets
3
Activities
1
Assay Types
4
PK Parameters
4
Publications
0
Known Names
Molecular Properties
611.8
MW (Da)
5.61
ALogP
10
HBA
2
HBD
113.8
PSA (Ų)
0.17
QED
2
Ro5 Violations
11
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 8.22 | 8.07 | 6.0 | 2 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 7.37 | 7.37 | 43.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 294.0 | ng.hr.mL-1 | Mus musculus |
| AUC | 323.0 | ng.hr.mL-1 | Rattus norvegicus |
| Cmax | 153.66 | nM | Mus musculus |
| Cmax | 65.39 | nM | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 6.0 | nM | 8.22 | Inhibition of mouse EGFR D770_N771insNPG mutant stably expressed in mouse BaF3 c... | 36423823 |
| Unchecked | IC50 | = | 12.0 | nM | 7.92 | Inhibition of mouse EGFR V769_D770insASV mutant stably expressed in mouse BaF3 c... | 36423823 |
| Epidermal growth factor receptor | IC50 | = | 43.0 | nM | 7.37 | Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated fo... | 36423823 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36423823 | 10.1016/j.bmcl.2022.129084 | ADMET | 4 |
| 36423823 | 10.1016/j.bmcl.2022.129084 | Unchecked | 2 |
| 36423823 | 10.1016/j.bmcl.2022.129084 | BaF3 | 2 |
| 36423823 | 10.1016/j.bmcl.2022.129084 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine