Assay Detail
Binding
CHEMBL5238848
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse EGFR V769_D770insASV mutant stably expressed in mouse BaF3 cells assessed as cell viability incubated for 3 days by Cell Titer-Glo assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.47 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5266100 | — | — | 1 | 8.40 |
| CHEMBL5266798 | — | — | 1 | 8.15 |
| CHEMBL5283216 | — | — | 1 | 8.03 |
| CHEMBL4650319 | MOBOCERTINIB | 4.0 | 1 | 7.96 |
| CHEMBL5290929 | — | — | 1 | 7.92 |
| CHEMBL5279794 | — | — | 1 | 7.91 |
| CHEMBL5270000 | — | — | 1 | 7.89 |
| CHEMBL5268143 | — | — | 1 | 7.89 |
| CHEMBL5270335 | — | — | 1 | 7.85 |
| CHEMBL5275712 | — | — | 1 | 7.82 |
| CHEMBL5284387 | — | — | 1 | 7.80 |
| CHEMBL5291353 | — | — | 1 | 7.80 |
| CHEMBL5281266 | — | — | 1 | 7.76 |
| CHEMBL5284486 | — | — | 1 | 7.75 |
| CHEMBL5286091 | — | — | 1 | 7.66 |
| CHEMBL5279491 | — | — | 1 | 7.60 |
| CHEMBL5273438 | — | — | 1 | 7.55 |
| CHEMBL5266834 | — | — | 1 | 7.55 |
| CHEMBL5271640 | — | — | 1 | 7.54 |
| CHEMBL5281203 | — | — | 1 | 7.52 |
| CHEMBL5284255 | — | — | 1 | 7.46 |
| CHEMBL5271718 | — | — | 1 | 7.42 |
| CHEMBL5272345 | — | — | 1 | 7.37 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.36 |
| CHEMBL5266482 | — | — | 1 | 7.24 |
| CHEMBL3353404 | — | — | 1 | 7.23 |
| CHEMBL5266896 | — | — | 1 | 6.95 |
| CHEMBL5276760 | — | — | 1 | 6.87 |
| CHEMBL5291010 | — | — | 1 | 6.86 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5266100 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5266798 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5283216 | — | IC50 | = | 9.38 | nM | 8.03 |
| CHEMBL4650319 | MOBOCERTINIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5290929 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5279794 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL5270000 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5268143 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5270335 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5275712 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5284387 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5291353 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5281266 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL5284486 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5286091 | — | IC50 | = | 22.1 | nM | 7.66 |
| CHEMBL5279491 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5273438 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5266834 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5271640 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5281203 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5284255 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5271718 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5272345 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5266482 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3353404 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5266896 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL5276760 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL5291010 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4104658 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL3545308 | ROCILETINIB | IC50 | = | 883.0 | nM | 6.05 |
| CHEMBL5286532 | — | IC50 | = | 1025.0 | nM | 5.99 |