Assay Detail
Functional
CHEMBL5238907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV-1 NLRepRlucP373S infected in human MT2 cells assessed as inhibition of viral growth measured after 4 to 5 days in presence of 10% FBS and 40% human serum supplemented with 27 mg/mL of human serum albumin by Dual luciferase reporter assay
26
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis, Structure-Activity Relationships, and <i>In Vivo</i> Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 7.46 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5277711 | — | — | 1 | 8.23 |
| CHEMBL5201510 | FIPRAVIRIMAT | 2.0 | 2 | 8.18 |
| CHEMBL5285267 | — | — | 1 | 8.03 |
| CHEMBL3827379 | BMS-955176 | 2.0 | 1 | 8.00 |
| CHEMBL5268258 | — | — | 1 | 7.89 |
| CHEMBL5282269 | — | — | 1 | 7.85 |
| CHEMBL5270022 | — | — | 1 | 7.80 |
| CHEMBL5272708 | — | — | 1 | 7.77 |
| CHEMBL5276163 | — | — | 1 | 7.75 |
| CHEMBL5276342 | — | — | 1 | 7.72 |
| CHEMBL5271451 | — | — | 1 | 7.72 |
| CHEMBL5287720 | — | — | 1 | 7.72 |
| CHEMBL5280223 | — | — | 1 | 7.62 |
| CHEMBL5281869 | — | — | 1 | 7.58 |
| CHEMBL5280411 | — | — | 1 | 7.57 |
| CHEMBL5273401 | — | — | 1 | 7.52 |
| CHEMBL5286848 | — | — | 1 | 7.52 |
| CHEMBL5275924 | — | — | 1 | 7.44 |
| CHEMBL5288711 | — | — | 1 | 7.28 |
| CHEMBL5274769 | — | — | 1 | 7.27 |
| CHEMBL5267277 | — | — | 1 | 7.08 |
| CHEMBL5287512 | — | — | 1 | 6.83 |
| CHEMBL5269871 | — | — | 1 | 6.01 |
| CHEMBL404519 | BEVIRIMAT | 2.0 | 1 | 6.01 |
| CHEMBL5271405 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5277711 | — | EC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5201510 | FIPRAVIRIMAT | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL5285267 | — | EC50 | = | 9.3 | nM | 8.03 |
| CHEMBL3827379 | BMS-955176 | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5268258 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5282269 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5201510 | FIPRAVIRIMAT | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5270022 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5272708 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5276163 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5276342 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5287720 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5271451 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5280223 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5281869 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5280411 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5286848 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5273401 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5275924 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5288711 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5274769 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5267277 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL5287512 | — | EC50 | = | 147.0 | nM | 6.83 |
| CHEMBL5269871 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL404519 | BEVIRIMAT | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL5271405 | — | EC50 | = | 1760.0 | nM | 5.75 |