Assay Detail
Functional
CHEMBL5238908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV-1 NLRepRlucP373S harboring V370A mutant infected in human MT2 cells assessed as inhibition of viral growth measured after 4 to 5 days by Dual luciferase reporter assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis, Structure-Activity Relationships, and <i>In Vivo</i> Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201510 | FIPRAVIRIMAT | 2.0 | 1 | 8.70 |
| CHEMBL5285267 | — | — | 1 | 8.52 |
| CHEMBL3827379 | BMS-955176 | 2.0 | 1 | 8.22 |
| CHEMBL4171418 | — | — | 1 | 8.00 |
| CHEMBL3787154 | — | — | 1 | 7.39 |
| CHEMBL3787473 | — | — | 1 | 6.82 |
| CHEMBL404519 | BEVIRIMAT | 2.0 | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201510 | FIPRAVIRIMAT | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5285267 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3827379 | BMS-955176 | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4171418 | — | EC50 | = | 9.9 | nM | 8.00 |
| CHEMBL3787154 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3787473 | — | EC50 | = | 152.0 | nM | 6.82 |
| CHEMBL404519 | BEVIRIMAT | EC50 | = | 552.0 | nM | 6.26 |