Assay Detail
Functional
CHEMBL5238916
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV-1 NLRepRlucP373S harboring R361K/V362I/L363M mutant infected in human MT2 cells assessed as inhibition of viral growth measured after 4 to 5 days by Dual luciferase reporter assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis, Structure-Activity Relationships, and <i>In Vivo</i> Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.34 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201510 | FIPRAVIRIMAT | 2.0 | 1 | 8.52 |
| CHEMBL5285267 | — | — | 1 | 8.35 |
| CHEMBL5268258 | — | — | 1 | 8.29 |
| CHEMBL5272708 | — | — | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201510 | FIPRAVIRIMAT | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5285267 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL5268258 | — | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5272708 | — | EC50 | = | 6.1 | nM | 8.21 |