Assay Detail
Binding
CHEMBL5239393
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LZK (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 13 (CHEMBL1163124) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.12 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393333 | — | — | 1 | 8.52 |
| CHEMBL5287658 | — | — | 1 | 8.00 |
| CHEMBL3732012 | GDC-0134 | 1.0 | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393333 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5287658 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3732012 | GDC-0134 | IC50 | = | 14.0 | nM | 7.85 |