Compound Detail
CHEMBL3732012
GDC-0134 Phase I
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Phase I
Nc1ncc(-c2cc(N3C[C@@H]4C[C@H]3CO4)nc(N3CCC(F)(F)C3)n2)cc1OC(F)F
Basic Information
| ChEMBL ID | CHEMBL3732012 |
| Name | GDC-0134 |
| Phase | Phase I |
| Structure Type | MOL |
| InChI Key | SKMKJBYBPYBDMN-RYUDHWBXSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
2
Known Names
1
Indications
Molecular Properties
440.4
MW (Da)
2.55
ALogP
8
HBA
1
HBD
89.6
PSA (Ų)
0.71
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Amyotrophic Lateral Sclerosis
Activity Summary
IC50 3 meas. best 7.96
Ki 1 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase kinase kinase 12 CHEMBL1908389 | Ki | 9.0 | 9.0 | 1.0 | 1 |
| Mitogen-activated protein kinase kinase kinase 12 CHEMBL1908389 | IC50 | 7.96 | 7.96 | 11.0 | 1 |
| Protein delta homolog 1 CHEMBL5671 | IC50 | 7.96 | 7.96 | 11.0 | 1 |
| Mitogen-activated protein kinase kinase kinase 13 CHEMBL1163124 | IC50 | 7.85 | 7.85 | 14.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase kinase kinase 12 | Ki | = | 1.0 | nM | 9.0 | Inhibition of N-terminally GST-tagged human DLK catalytic domain (1 to 520 amino... | - |
| Mitogen-activated protein kinase kinase kinase 12 | IC50 | = | 11.0 | nM | 7.96 | Inhibition of DLK (unknown origin) | 36469401 |
| Protein delta homolog 1 | IC50 | = | 11.0 | nM | 7.96 | Inhibition of DLK (unknown origin) | 37098296 |
| Mitogen-activated protein kinase kinase kinase 13 | IC50 | = | 14.0 | nM | 7.85 | Inhibition of LZK (unknown origin) | 36469401 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36469401 | 10.1021/acs.jmedchem.2c01056 | Mitogen-activated protein kinase kinase kinase 12 | 1 |
| 36469401 | 10.1021/acs.jmedchem.2c01056 | Mitogen-activated protein kinase kinase kinase 13 | 1 |
| 37098296 | 10.1016/j.ejmech.2023.115404 | Protein delta homolog 1 | 1 |
Data from ChEMBL 36 via Core Engine