Assay Detail
Binding
CHEMBL5239595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli by ITC assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.28 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5276223 | — | — | 1 | 8.22 |
| CHEMBL5268339 | — | — | 1 | 7.89 |
| CHEMBL5283388 | — | — | 1 | 7.80 |
| CHEMBL5280970 | — | — | 1 | 7.58 |
| CHEMBL5290760 | — | — | 1 | 6.39 |
| CHEMBL9352 | NARINGENIN | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5276223 | — | Kd | = | 6.0 | nM | 8.22 |
| CHEMBL5268339 | — | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL5283388 | — | Kd | = | 16.0 | nM | 7.80 |
| CHEMBL5280970 | — | Kd | = | 26.0 | nM | 7.58 |
| CHEMBL5290760 | — | Kd | = | 403.0 | nM | 6.39 |
| CHEMBL9352 | NARINGENIN | Kd | = | 1630.0 | nM | 5.79 |