Compound Detail
CHEMBL5290760
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Basic Information
| ChEMBL ID | CHEMBL5290760 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GOSBDBOXKLAPRA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
306.7
MW (Da)
3.16
ALogP
5
HBA
3
HBD
87.0
PSA (Ų)
0.75
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 6.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transthyretin CHEMBL3194 | Kd | 6.39 | 6.39 | 403.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transthyretin | Kd | = | 403.0 | nM | 6.39 | Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia co... | 36472374 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36472374 | 10.1021/acs.jmedchem.2c00511 | Transthyretin | 6 |
Data from ChEMBL 36 via Core Engine