Assay Detail
Functional
CHEMBL5239772
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Cytotoxicity against human Huh-7 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2-Amino-7-sulfonyl-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidine Derivatives as Potent Reversible FGFR Inhibitors with Gatekeeper Mutation Tolerance: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.58 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4514636 | FISOGATINIB | 2.0 | 1 | 7.34 |
| CHEMBL5278656 | — | — | 1 | 7.02 |
| CHEMBL5281307 | — | — | 1 | 6.88 |
| CHEMBL5289886 | — | — | 1 | 6.78 |
| CHEMBL5283096 | — | — | 1 | 6.72 |
| CHEMBL5280802 | — | — | 1 | 6.62 |
| CHEMBL5290554 | — | — | 1 | 6.61 |
| CHEMBL5268564 | — | — | 1 | 6.53 |
| CHEMBL5283169 | — | — | 1 | 6.52 |
| CHEMBL5268351 | — | — | 1 | 6.51 |
| CHEMBL5280110 | — | — | 1 | 6.42 |
| CHEMBL5290407 | — | — | 1 | 6.42 |
| CHEMBL5283222 | — | — | 1 | 6.35 |
| CHEMBL5267668 | — | — | 1 | 6.35 |
| CHEMBL5279776 | — | — | 1 | 6.35 |
| CHEMBL5275506 | — | — | 1 | 6.27 |
| CHEMBL5272254 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4514636 | FISOGATINIB | IC50 | = | 45.9 | nM | 7.34 |
| CHEMBL5278656 | — | IC50 | = | 94.7 | nM | 7.02 |
| CHEMBL5281307 | — | IC50 | = | 131.4 | nM | 6.88 |
| CHEMBL5289886 | — | IC50 | = | 166.4 | nM | 6.78 |
| CHEMBL5283096 | — | IC50 | = | 191.1 | nM | 6.72 |
| CHEMBL5280802 | — | IC50 | = | 240.1 | nM | 6.62 |
| CHEMBL5290554 | — | IC50 | = | 244.5 | nM | 6.61 |
| CHEMBL5268564 | — | IC50 | = | 298.2 | nM | 6.53 |
| CHEMBL5283169 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL5268351 | — | IC50 | = | 310.1 | nM | 6.51 |
| CHEMBL5280110 | — | IC50 | = | 382.9 | nM | 6.42 |
| CHEMBL5290407 | — | IC50 | = | 376.7 | nM | 6.42 |
| CHEMBL5283222 | — | IC50 | = | 449.0 | nM | 6.35 |
| CHEMBL5267668 | — | IC50 | = | 451.2 | nM | 6.35 |
| CHEMBL5279776 | — | IC50 | = | 443.7 | nM | 6.35 |
| CHEMBL5275506 | — | IC50 | = | 534.2 | nM | 6.27 |
| CHEMBL5272254 | — | IC50 | = | 811.4 | nM | 6.09 |