Assay Detail
Functional
CHEMBL5239777
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse BaF3 cells expressing TEL-fused FGFR4 V550L mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2-Amino-7-sulfonyl-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidine Derivatives as Potent Reversible FGFR Inhibitors with Gatekeeper Mutation Tolerance: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.37 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5278656 | — | — | 1 | 6.58 |
| CHEMBL5283096 | — | — | 1 | 6.42 |
| CHEMBL5290554 | — | — | 1 | 6.39 |
| CHEMBL5281307 | — | — | 1 | 6.27 |
| CHEMBL5289886 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5278656 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5283096 | — | IC50 | = | 376.2 | nM | 6.42 |
| CHEMBL5290554 | — | IC50 | = | 405.2 | nM | 6.39 |
| CHEMBL5281307 | — | IC50 | = | 533.9 | nM | 6.27 |
| CHEMBL5289886 | — | IC50 | = | 631.6 | nM | 6.20 |