Assay Detail
Functional
CHEMBL5239927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine sensitive Plasmodium falciparum NF54 incubated for 72 hrs by microplate reader assay
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and <i>In Vivo</i> Efficacy in a <i>Plasmodium berghei</i> Mouse Malaria Infection Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 6.59 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.40 |
| CHEMBL5273140 | — | — | 1 | 7.92 |
| CHEMBL5286466 | — | — | 1 | 7.68 |
| CHEMBL5283963 | — | — | 1 | 7.66 |
| CHEMBL5267878 | — | — | 1 | 7.52 |
| CHEMBL5280818 | — | — | 1 | 7.48 |
| CHEMBL4845682 | — | — | 1 | 7.37 |
| CHEMBL5275583 | — | — | 1 | 7.36 |
| CHEMBL5270015 | — | — | 1 | 7.29 |
| CHEMBL5274888 | — | — | 1 | 7.26 |
| CHEMBL5286751 | — | — | 1 | 7.19 |
| CHEMBL5267563 | — | — | 1 | 7.18 |
| CHEMBL5272240 | — | — | 1 | 7.13 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 1 | 7.07 |
| CHEMBL5265992 | — | — | 1 | 7.05 |
| CHEMBL5285111 | — | — | 1 | 7.03 |
| CHEMBL5273046 | — | — | 1 | 7.01 |
| CHEMBL5271875 | — | — | 1 | 6.98 |
| CHEMBL5277337 | — | — | 1 | 6.79 |
| CHEMBL5271454 | — | — | 1 | 6.52 |
| CHEMBL5289580 | — | — | 1 | 6.51 |
| CHEMBL5279364 | — | — | 1 | 6.42 |
| CHEMBL5269022 | — | — | 1 | 6.38 |
| CHEMBL5269262 | — | — | 1 | 6.35 |
| CHEMBL5291291 | — | — | 1 | 6.35 |
| CHEMBL5278423 | — | — | 1 | 6.34 |
| CHEMBL5274893 | — | — | 1 | 6.32 |
| CHEMBL5270615 | — | — | 1 | 6.31 |
| CHEMBL5275108 | — | — | 1 | 6.30 |
| CHEMBL5283931 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5273140 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5286466 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5283963 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5267878 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5280818 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4845682 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5275583 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5270015 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5274888 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5286751 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5267563 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5272240 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5265992 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL5285111 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL5273046 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL5271875 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL5277337 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL5271454 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL5289580 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL5279364 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL5269022 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL5269262 | — | IC50 | = | 446.0 | nM | 6.35 |
| CHEMBL5291291 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL5278423 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5274893 | — | IC50 | = | 484.0 | nM | 6.32 |
| CHEMBL5270615 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL5275108 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL5283931 | — | IC50 | = | 515.0 | nM | 6.29 |
| CHEMBL5287948 | — | IC50 | = | 519.0 | nM | 6.29 |
| CHEMBL5287964 | — | IC50 | = | 514.0 | nM | 6.29 |
| CHEMBL5285675 | — | IC50 | = | 567.0 | nM | 6.25 |
| CHEMBL5287098 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL5278234 | — | IC50 | = | 702.0 | nM | 6.15 |
| CHEMBL5282075 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL5278756 | — | IC50 | = | 831.0 | nM | 6.08 |
| CHEMBL5273748 | — | IC50 | = | 834.0 | nM | 6.08 |
| CHEMBL5270174 | — | IC50 | = | 1161.0 | nM | 5.93 |
| CHEMBL5281070 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL5276272 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL5286661 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL5274655 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL5267185 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL5288925 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL5285301 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL5275908 | — | IC50 | = | 4651.0 | nM | 5.33 |
| CHEMBL5269574 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL5282213 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL5271575 | — | IC50 | > | 6000.0 | nM | - |