Compound Detail
CHEMBL5285111
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5285111 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YAQBXXOZSCQWBP-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
498.7
MW (Da)
6.09
ALogP
7
HBA
1
HBD
72.0
PSA (Ų)
0.32
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 7.03 | 6.92 | 93.0 | 2 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 6.05 | 6.05 | 890.0 | 1 |
| CHO CHEMBL613853 | IC50 | 4.35 | 4.35 | 44400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 93.0 | nM | 7.03 | Antiplasmodial activity against chloroquine sensitive Plasmodium falciparum NF54... | 36507890 |
| Plasmodium falciparum | IC50 | = | 156.0 | nM | 6.81 | Antiplasmodial activity against multidrug resistant Plasmodium falciparum K1 inc... | 36507890 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 890.0 | nM | 6.05 | Inhibition of human ERG expressed in CHO-K1 cells by Q-patch clamp assay | 36507890 |
| CHO | IC50 | = | 44400.0 | nM | 4.35 | Cytotoxicity against CHO cells measured after 48 hrs by MTT assay | 36507890 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36507890 | 10.1021/acs.jmedchem.2c01516 | Plasmodium falciparum | 3 |
| 36507890 | 10.1021/acs.jmedchem.2c01516 | No relevant target | 1 |
| 36507890 | 10.1021/acs.jmedchem.2c01516 | CHO | 1 |
| 36507890 | 10.1021/acs.jmedchem.2c01516 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 36507890 | 10.1021/acs.jmedchem.2c01516 | ADMET | 1 |
| 36507890 | 10.1021/acs.jmedchem.2c01516 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine