Assay Detail
Toxicity
CHEMBL5239936
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Cytotoxicity against CHO cells measured after 48 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and <i>In Vivo</i> Efficacy in a <i>Plasmodium berghei</i> Mouse Malaria Infection Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.14 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5283963 | — | — | 1 | 6.12 |
| CHEMBL5273140 | — | — | 1 | 5.71 |
| CHEMBL5267563 | — | — | 1 | 5.50 |
| CHEMBL5267878 | — | — | 1 | 5.48 |
| CHEMBL5274888 | — | — | 1 | 5.45 |
| CHEMBL5286466 | — | — | 1 | 5.42 |
| CHEMBL5286751 | — | — | 1 | 5.33 |
| CHEMBL5275583 | — | — | 1 | 5.25 |
| CHEMBL5270015 | — | — | 1 | 5.23 |
| CHEMBL5280818 | — | — | 1 | 5.04 |
| CHEMBL4845682 | — | — | 1 | 4.91 |
| CHEMBL5265992 | — | — | 1 | 4.78 |
| CHEMBL5273046 | — | — | 1 | 4.71 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 1 | 4.53 |
| CHEMBL5272240 | — | — | 1 | 4.41 |
| CHEMBL5285111 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5283963 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5273140 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL5267563 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL5267878 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL5274888 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL5286466 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL5286751 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL5275583 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL5270015 | — | IC50 | = | 5870.0 | nM | 5.23 |
| CHEMBL5280818 | — | IC50 | = | 9080.0 | nM | 5.04 |
| CHEMBL4845682 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL5265992 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL5273046 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL5272240 | — | IC50 | = | 38900.0 | nM | 4.41 |
| CHEMBL5285111 | — | IC50 | = | 44400.0 | nM | 4.35 |